Dr Raimondo Bruno is an Associate Professor in the School of Medicine at the University of Tasmania. His main research interests include the cognitive consequences of use of medications and illicit drugs; illicit drug market trends; and approaches to reduce the harms associated with substance use. He has active research collaborations with key national research centres in the substance use field and holds conjoint positions at Turning Point Alcohol and Drug Centre, and the National Drug and Alcohol Research Centre, University of New South Wales.
Take Home Points:
• An important component of natural cannabis is cannabidiol which has protective effects against some of the adverse influences of THC.
• THC binds strongly to CB1 and CB2 but is a partial agonist, whereas the synthetic cannabinoids are typically full agonists.
• Synthetic cannabinoids bring a risk of the serotonergic syndrome and some have MAO inhibitory effects.