Synthetic Cannabinoids Tainted With Rat Poison

Hematologist Tom Deloughery discusses recent cases of severe bleeding caused by use of synthetic marijuana tainted with the rodenticide brodifacoum. Brodifacoum is a vitamin K antagonist 10 times stronger than warfarin with a 20-30 day half life.

On lab testing, both INR and PTT are elevated, but fibrinogen unchanged.

Vitamin K is the antidote and requires prolonged treatment at high doses (up to 100mg per dose).

Consider giving prothrombin complex concentrate in patients with CNS or potential life threatening bleeding.

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